In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana
Identifieur interne : 000F70 ( Main/Exploration ); précédent : 000F69; suivant : 000F71In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana
Auteurs : Kathleen M. Powis [États-Unis, Botswana] ; Laura Smeaton [États-Unis] ; Michael D. Hughes [États-Unis] ; Esther A. Tumbare [Zimbabwe] ; Sajini Souda [États-Unis] ; Jennifer Jao [États-Unis] ; Katlheen E. Wirth [États-Unis] ; Joseph Makhema [Botswana] ; Shahin Lockman [États-Unis, Botswana] ; Wafaie Fawzi [États-Unis] ; Max Essex [États-Unis, Botswana] ; Roger Shapiro [États-Unis, Botswana]Source :
- AIDS (London, England) [ 0269-9370 ] ; 2016.
Abstract
To assess associations between in-utero triple antiretrovirals (cART) versus zidovudine (ZDV) monotherapy exposure and growth among HIV-uninfected children of HIV-infected women in Botswana.
Secondary retrospective data analysis from two randomized intervention trials of mother-to-child HIV transmission prevention.
The Mashi and Mma Bana studies enrolled HIV-infected pregnant women, following their children through 24 months of age. This analysis includes singleton, full-term, HIV-exposed uninfected children. Mothers received cART or ZDV at least 2 weeks predelivery, and breastfed up to 6 months. Weight-for-age (WAZ), length-for-age (LAZ) and weight-for-length (WLZ) z-scores were derived. Mean z-scores were compared by exposure group at 24 months (
Of 819 children, 303 were ZDV- and 516 cART-exposed
At 24 months, in-utero cART-exposed children had significantly lower LAZ and WAZ. Poor growth impacts childhood and adult mortality. These findings raise concerns for potential lasting health impacts among HIV-exposed uninfected children with in-utero cART exposure.
Url:
DOI: 10.1097/QAD.0000000000000895
PubMed: 26684818
PubMed Central: 4685731
Affiliations:
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<author><name sortKey="Tumbare, Esther A" sort="Tumbare, Esther A" uniqKey="Tumbare E" first="Esther A." last="Tumbare">Esther A. Tumbare</name>
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<author><name sortKey="Makhema, Joseph" sort="Makhema, Joseph" uniqKey="Makhema J" first="Joseph" last="Makhema">Joseph Makhema</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts</wicri:regionArea>
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<country xml:lang="fr">Botswana</country>
<wicri:regionArea>Botswana Harvard AIDS Institute Partnership, Gaborone</wicri:regionArea>
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<affiliation wicri:level="2"><nlm:aff id="A9">Infectious Disease Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Fawzi, Wafaie" sort="Fawzi, Wafaie" uniqKey="Fawzi W" first="Wafaie" last="Fawzi">Wafaie Fawzi</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Essex, Max" sort="Essex, Max" uniqKey="Essex M" first="Max" last="Essex">Max Essex</name>
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<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="1"><nlm:aff id="A3">Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana</nlm:aff>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
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<affiliation wicri:level="1"><nlm:aff id="A3">Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana</nlm:aff>
<country xml:lang="fr">Botswana</country>
<wicri:regionArea>Botswana Harvard AIDS Institute Partnership, Gaborone</wicri:regionArea>
<wicri:noRegion>Gaborone</wicri:noRegion>
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<affiliation wicri:level="2"><nlm:aff id="A11">Beth Israel Deaconess Medical Center, Infectious Diseases Department, Boston, Massachusetts, USA</nlm:aff>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">To assess associations between in-utero triple antiretrovirals (cART) versus zidovudine (ZDV) monotherapy exposure and growth among HIV-uninfected children of HIV-infected women in Botswana.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">Secondary retrospective data analysis from two randomized intervention trials of mother-to-child HIV transmission prevention.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">The Mashi and Mma Bana studies enrolled HIV-infected pregnant women, following their children through 24 months of age. This analysis includes singleton, full-term, HIV-exposed uninfected children. Mothers received cART or ZDV at least 2 weeks predelivery, and breastfed up to 6 months. Weight-for-age (WAZ), length-for-age (LAZ) and weight-for-length (WLZ) z-scores were derived. Mean z-scores were compared by exposure group at 24 months (<italic>t</italic>
-test, linear regression).</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">Of 819 children, 303 were ZDV- and 516 cART-exposed <italic>in utero</italic>
. Maternal median enrolment CD4<sup>+</sup>
was higher among ZDV versus cART-treated mothers (393 versus 324 cells/µl; <italic>P</italic>
< 0.0001). Median duration of antepartum antiretroviral use was shorter among ZDV-treated women (5.7 versus 12.0 weeks; <italic>P</italic>
< 0.0001). Median months breastfed were similar (5.9 and 6.0; <italic>P</italic>
= 0.43). At 24 months, mean LAZ and WAZ were significantly lower among cART-exposed children (LAZ −1.01 versus −0.74; <italic>P</italic>
= 0.003) (WAZ −0.53 versus −0.30; <italic>P</italic>
= 0.002) in unadjusted analyses. Adjusting for maternal CD4<sup>+</sup>
, viral load, enrolment site and maternal anthropometric measures, cART-exposed children had significantly lower LAZ and WAZ at 24 months (<italic>P</italic>
= 0.0004 for both).</p>
</sec>
<sec id="S5"><title>Conclusion</title>
<p id="P5">At 24 months, in-utero cART-exposed children had significantly lower LAZ and WAZ. Poor growth impacts childhood and adult mortality. These findings raise concerns for potential lasting health impacts among HIV-exposed uninfected children with in-utero cART exposure.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Botswana</li>
<li>Zimbabwe</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Powis, Kathleen M" sort="Powis, Kathleen M" uniqKey="Powis K" first="Kathleen M." last="Powis">Kathleen M. Powis</name>
</region>
<name sortKey="Essex, Max" sort="Essex, Max" uniqKey="Essex M" first="Max" last="Essex">Max Essex</name>
<name sortKey="Fawzi, Wafaie" sort="Fawzi, Wafaie" uniqKey="Fawzi W" first="Wafaie" last="Fawzi">Wafaie Fawzi</name>
<name sortKey="Hughes, Michael D" sort="Hughes, Michael D" uniqKey="Hughes M" first="Michael D." last="Hughes">Michael D. Hughes</name>
<name sortKey="Jao, Jennifer" sort="Jao, Jennifer" uniqKey="Jao J" first="Jennifer" last="Jao">Jennifer Jao</name>
<name sortKey="Lockman, Shahin" sort="Lockman, Shahin" uniqKey="Lockman S" first="Shahin" last="Lockman">Shahin Lockman</name>
<name sortKey="Lockman, Shahin" sort="Lockman, Shahin" uniqKey="Lockman S" first="Shahin" last="Lockman">Shahin Lockman</name>
<name sortKey="Powis, Kathleen M" sort="Powis, Kathleen M" uniqKey="Powis K" first="Kathleen M." last="Powis">Kathleen M. Powis</name>
<name sortKey="Shapiro, Roger" sort="Shapiro, Roger" uniqKey="Shapiro R" first="Roger" last="Shapiro">Roger Shapiro</name>
<name sortKey="Shapiro, Roger" sort="Shapiro, Roger" uniqKey="Shapiro R" first="Roger" last="Shapiro">Roger Shapiro</name>
<name sortKey="Smeaton, Laura" sort="Smeaton, Laura" uniqKey="Smeaton L" first="Laura" last="Smeaton">Laura Smeaton</name>
<name sortKey="Souda, Sajini" sort="Souda, Sajini" uniqKey="Souda S" first="Sajini" last="Souda">Sajini Souda</name>
<name sortKey="Wirth, Katlheen E" sort="Wirth, Katlheen E" uniqKey="Wirth K" first="Katlheen E." last="Wirth">Katlheen E. Wirth</name>
</country>
<country name="Botswana"><noRegion><name sortKey="Powis, Kathleen M" sort="Powis, Kathleen M" uniqKey="Powis K" first="Kathleen M." last="Powis">Kathleen M. Powis</name>
</noRegion>
<name sortKey="Essex, Max" sort="Essex, Max" uniqKey="Essex M" first="Max" last="Essex">Max Essex</name>
<name sortKey="Lockman, Shahin" sort="Lockman, Shahin" uniqKey="Lockman S" first="Shahin" last="Lockman">Shahin Lockman</name>
<name sortKey="Makhema, Joseph" sort="Makhema, Joseph" uniqKey="Makhema J" first="Joseph" last="Makhema">Joseph Makhema</name>
<name sortKey="Shapiro, Roger" sort="Shapiro, Roger" uniqKey="Shapiro R" first="Roger" last="Shapiro">Roger Shapiro</name>
</country>
<country name="Zimbabwe"><noRegion><name sortKey="Tumbare, Esther A" sort="Tumbare, Esther A" uniqKey="Tumbare E" first="Esther A." last="Tumbare">Esther A. Tumbare</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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